Acetic Anhydride → Methyl 4-acetoxy-3-cyanobenzoate

HRID 234771노트

반응식

HRID 234771 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:3]=1[CH:4]=[N:5]O.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([O:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:3]=1[C:4]#[N:5])(=[O:17])[CH3:16]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 1363810712-Hydroxy-5-methoxycarbonyl-benzaldehyde oxime

생성물 1

HCID 54012634Methyl 4-acetoxy-3-cyanobenzoate

실험 절차

70.3 g (0.36 mol) of the compound from Example XXXVII are stirred under reflux in 0.5 l of acetic anhydride for 1.5 hours. The mixture is concentrated to dryness, the residue is dissolved in methylene chloride and the title compound is crystallised out by addition of petroleum ether.

후처리

  1. concentrationThe mixture is concentrated to dryness
  2. dissolutionthe residue is dissolved in methylene chloride
  3. customthe title compound is crystallised out by addition of petroleum ether

출처 및 근거

ORD 기록
ord-a6ca8db106ed4370bf752b1bee560b42
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05596006

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