Acetonitrile → 4-Difluoromethoxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

HRID 2348062Notes

Reaction equation

HRID 2348062 reaction equation
[CH3:31][C:32]#[N:33].[Cu:29][I:30].[F:19][C:20]([S:21]([F:22])(=[O:23])=[O:24])([C:25]([OH:26])=[O:27])[F:28].[OH:1][CH2:2][CH:3]1[CH2:4][CH:5]([C:15](=[O:16])[O:17][CH3:18])[N:6]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:7]1>>[O:1]([CH2:2][CH:3]1[CH2:4][CH:5]([C:15](=[O:16])[O:17][CH3:18])[N:6]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:7]1)[CH:20]([F:19])[F:28]

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27375162,2-Difluoro-2-(fluorosulfonyl)acetic acidHCID 235957531-(tert-Butyl) 2-methyl 4-(hydroxymethyl)pyrrolidine-1,2-dicarboxylate

Product 1

HCID 666204384-Difluoromethoxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Sources & evidence

ORD record
ord-f0ab543e5abd4863ab7b7517021ebe66
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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