Dimethyl Sulfoxide → 8-Amino-9-fluoro-7-oxo-10-(3-(pyridin-2-yl)propylamino)-2,7-dihydrospiro[[1,4]oxazino[2,3,4-ij]quinoline-3,1'-cyclopropane]-6-carbonitrile

HRID 2348599Notes

Reaction equation

HRID 2348599 reaction equation
[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[CH3:40][S:41]([CH3:42])=[O:43].[NH2:1][c:2]1[c:3]2[c:4](=[O:21])[c:5]([C:19]#[N:20])[cH:6][n:7]3[c:8]2[c:9]([c:10]([F:13])[c:11]1[F:12])[O:14][CH2:15][C:16]31[CH2:17][CH2:18]1.[OH2:39].[n:22]1[c:23]([CH2:28][CH2:29][CH2:30][NH2:31])[cH:24][cH:25][cH:26][cH:27]1>>[NH2:1][c:2]1[c:3]2[c:4](=[O:21])[c:5]([C:19]#[N:20])[cH:6][n:7]3[c:8]2[c:9]([c:10]([NH:31][CH2:30][CH2:29][CH2:28][c:23]2[n:22][cH:27][cH:26][cH:25][cH:24]2)[c:11]1[F:12])[O:14][CH2:15][C:16]31[CH2:17][CH2:18]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 8471TriethylamineHCID 31596143-(Pyridin-2-yl)propan-1-amineHCID 581346818-Amino-9,10-difluoro-7-oxo-2,7-dihydrospiro[[1,4]oxazino-[2,3,4-ij]quinoline-3,1'-cyclopropane]-6-carbonitrile

Product 1

HCID 252527558-Amino-9-fluoro-7-oxo-10-(3-(pyridin-2-yl)propylamino)-2,7-dihydrospiro[[1,4]oxazino[2,3,4-ij]quinoline-3,1'-cyclopropane]-6-carbonitrile

Sources & evidence

ORD record
ord-e0590d4a34d747eb91252a5158e1325d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…