Sodium ion → 7-Chloro-3-(2,6-dichloro-pyridin-4-yl)-imidazo[1,2-a]pyridine

HRID 2348758Notes

Reaction equation

HRID 2348758 reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]2[n:6]1[cH:7][cH:8][c:9]([Cl:11])[cH:10]2.[C:30](=[O:31])([O-:32])[O-:33].[CH3:36][O:37][CH2:38][CH2:39][O:40][CH3:41].[Cl:12][c:13]1[n:14][c:15]([Cl:28])[cH:16][c:17]([B:19]2[O:20][C:21]([CH3:22])([CH3:23])[C:24]([CH3:25])([CH3:26])[O:27]2)[cH:18]1.[Na+:34].[Na+:35].[OH2:29].[Pd:42]([Cl:43])[Cl:44].[c:45]1([P:46]([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[cH:59][cH:60][cH:61][cH:62][cH:63]1.[c:64]1([P:65]([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[cH:78][cH:79][cH:80][cH:81][cH:82]1>>[c:2]1(-[c:17]2[cH:16][c:15]([Cl:28])[n:14][c:13]([Cl:12])[cH:18]2)[cH:3][n:4][c:5]2[n:6]1[cH:7][cH:8][c:9]([Cl:11])[cH:10]2

Participants

9

Reactant 8

HCID 923Sodium ion2×HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 11776Triphenylphosphine2×HCID 19660Carbonate IonHCID 24290Palladium ChlorideHCID 445163862,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 467391183-Bromo-7-chloroimidazo[1,2-a]pyridine

Product 1

HCID 866443467-Chloro-3-(2,6-dichloro-pyridin-4-yl)-imidazo[1,2-a]pyridine

Sources & evidence

ORD record
ord-4dd2e6fe42934342a2dfe2d828fad1d6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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