Hydrogen Bromide → HCID 15672517, compound

225 g (1.46 mol) of cyclopropyl-2-thienylcarbinol were added dropwise to 972 ml of 48% strength hydrobromic acid at from 5° to 10° C. in the course of 1 hour. After 2 hours at room temperature, the organic phase was separated off and the aqueous solution was extracted with three times 300 ml of dichloromethane. The combined organic phases were washed neutral with dilute sodium hydroxide solution and water, dried over magnesium sulfate and evaporated under reduced pressure. 322 g (94% corrected) of crude bromide were obtained (GC: 92%).

1. customthe organic phase was separated off
2. extractionthe aqueous solution was extracted with three times 300 ml of dichloromethane
3. washThe combined organic phases were washed neutral with dilute sodium hydroxide solution and water
4. dry with materialdried over magnesium sulfate
5. customevaporated under reduced pressure

ORD record

ord-0745c67221ba4254b2e7943c612a74a0

Source dataset

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05597776