反应详情

温度

20 °C

60 ml of 40% strength by weight aqueous potassium hydroxide solution were added to a suspension of 90 g (0.66 mol) of 4-amino-5-formyl-2-methylpyrimidine and 88.7 g (0.66 mol) of p-fluorophenylacetonitrile in 900 ml of methanol at 40° C., a homogeneous solution being formed. After cooling to about 20° C., the precipitate formed was separated off. 1 l of water was added to the alcoholic phase, with the result that further product crystallized out. Yield: 78%; mp.: 252°-254° C.

1. customa homogeneous solution being formed
2. customthe precipitate formed
3. customwas separated off
4. addition1 l of water was added to the alcoholic phase
5. customwith the result that further product
6. customcrystallized out