Potassium Hydroxide → HCID 53828116, compound

HRID 234880Notes

Reaction equation

HRID 234880 reaction equation
[OH-].[K+].[NH2:3][C:4]1[C:9]([CH:10]=O)=[CH:8][N:7]=[C:6]([CH3:12])[N:5]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21]#[N:22])=[CH:16][CH:15]=1>CO>[NH2:22][C:21]1[C:20]([C:17]2[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=2)=[CH:10][C:9]2[CH:8]=[N:7][C:6]([CH3:12])=[N:5][C:4]=2[N:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 68016Benzeneacetonitrile, 4-fluoro-HCID 129047264-Amino-2-methylpyrimidine-5-carbaldehyde

Product 1

HCID 53828116HCID 53828116, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

60 ml of 40% strength by weight aqueous potassium hydroxide solution were added to a suspension of 90 g (0.66 mol) of 4-amino-5-formyl-2-methylpyrimidine and 88.7 g (0.66 mol) of p-fluorophenylacetonitrile in 900 ml of methanol at 40° C., a homogeneous solution being formed. After cooling to about 20° C., the precipitate formed was separated off. 1 l of water was added to the alcoholic phase, with the result that further product crystallized out. Yield: 78%; mp.: 252°-254° C.

Workup

  1. customa homogeneous solution being formed
  2. customthe precipitate formed
  3. customwas separated off
  4. addition1 l of water was added to the alcoholic phase
  5. customwith the result that further product
  6. customcrystallized out

Sources & evidence

ORD record
ord-a229c7535d8049faaa097706368e07f7
Source dataset
uspto-grants-1997_01
Patent number
US05597776

Reaction notes

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