HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 234880Generated: October 27, 2026
Potassium Hydroxide → HCID 53828116, compound
https://huagongshe.com/reaction/234880
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzeneacetonitrile, 4-fluoro- | HCID 68016 | — |
| Reactant | 4-Amino-2-methylpyrimidine-5-carbaldehyde | HCID 12904726 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 53828116 | HCID 53828116 | 78% |
Reaction Steps
60 ml of 40% strength by weight aqueous potassium hydroxide solution were added to a suspension of 90 g (0.66 mol) of 4-amino-5-formyl-2-methylpyrimidine and 88.7 g (0.66 mol) of p-fluorophenylacetonitrile in 900 ml of methanol at 40° C., a homogeneous solution being formed. After cooling to about 20° C., the precipitate formed was separated off. 1 l of water was added to the alcoholic phase, with the result that further product crystallized out. Yield: 78%; mp.: 252°-254° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05597776 |
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| Source dataset | uspto-grants-1997_01 |
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| ORD ID | ord-a229c7535d8049faaa097706368e07f7 |
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| Source note | uspto-grants-1997_01 |
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