Dichloromethane → (2-morpholin-4-yl-ethyl)-(3-{3-[(thiophen-3-ylmethyl)-amino]-phenyl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-amine

HRID 2348975Notes

Reaction equation

HRID 2348975 reaction equation
[Cl:47][CH2:48][Cl:49].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][c:10]2[n:11][cH:12][c:13]3[c:14]([n:15]2)[n:16]([CH2:32][O:33][CH2:34][CH2:35][Si:36]([CH3:37])([CH3:38])[CH3:39])[n:17][c:18]3-[c:19]2[cH:20][c:21]([NH:25][CH2:26][c:27]3[cH:28][s:29][cH:30][cH:31]3)[cH:22][cH:23][cH:24]2)[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][c:10]2[n:11][cH:12][c:13]3[c:14]([n:15]2)[nH:16][n:17][c:18]3-[c:19]2[cH:20][c:21]([NH:25][CH2:26][c:27]3[cH:28][s:29][cH:30][cH:31]3)[cH:22][cH:23][cH:24]2)[CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68108621(2-morpholin-4-yl-ethyl)-[3-{3-[(thiophen-3-ylmethyl)-amino]-phenyl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-amine

Product 1

HCID 178420615(2-morpholin-4-yl-ethyl)-(3-{3-[(thiophen-3-ylmethyl)-amino]-phenyl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-amine

Sources & evidence

ORD record
ord-f416cb4c8d404e3988d96311fd4cae3b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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