Dichloromethane → 2-[4-(5-Pyrimidin-2-ylpent-1-enylsulfonyl)piperazin-1-yl]-5-(2,2,2-trifluoroethoxy)pyrimidine

HRID 2349323Notes

Reaction equation

HRID 2349323 reaction equation
[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:41][S:42](=[O:43])(=[O:44])[Cl:45].[Cl:46][CH2:47][Cl:48].[n:1]1[c:2]([CH2:7][CH2:8][CH2:9][CH:10]([CH2:11][S:12](=[O:13])(=[O:14])[N:15]2[CH2:16][CH2:17][N:18]([c:21]3[n:22][cH:23][c:24]([O:27][CH2:28][C:29]([F:30])([F:31])[F:32])[cH:25][n:26]3)[CH2:19][CH2:20]2)[OH:33])[n:3][cH:4][cH:5][cH:6]1>>[n:1]1[c:2]([CH2:7][CH2:8][CH2:9][CH:10]=[CH:11][S:12](=[O:13])(=[O:14])[N:15]2[CH2:16][CH2:17][N:18]([c:21]3[n:22][cH:23][c:24]([O:27][CH2:28][C:29]([F:30])([F:31])[F:32])[cH:25][n:26]3)[CH2:19][CH2:20]2)[n:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 688486265-Pyrimidin-2-yl-1-({4-[5-(2,2,2-trifluoroethoxy)pyrimidin-2-yl]piperazin-1-yl}sulfonyl)pentan-2-ol

Product 1

HCID 688456552-[4-(5-Pyrimidin-2-ylpent-1-enylsulfonyl)piperazin-1-yl]-5-(2,2,2-trifluoroethoxy)pyrimidine

Sources & evidence

ORD record
ord-08b880fcac954faaa07dc8281a6c6ea0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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