2,5-Dichlorobenzylic alcohol → 2,4-Diamino-5-(2,5-dichlorophenyl)-6-methylpyrimidine

HRID 234938Notes

Reaction equation

HRID 234938 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11](Cl)[C:10]=2[Cl:17])=[C:4]([CH3:18])[N:3]=1.ClC1C=CC(Cl)=CC=1CO>C(Cl)(Cl)Cl.CO>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[Cl:17])=[C:4]([CH3:18])[N:3]=1

Participants

4

Reactant 2

HCID 1186042,5-Dichlorobenzylic alcoholHCID 115512322,4-Diamino-6-methyl-5-(2,3,5-trichlorophenyl)pyrimidine

Product 1

HCID 197051162,4-Diamino-5-(2,5-dichlorophenyl)-6-methylpyrimidine

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

This compound was made in an analogous manner to the compound of Example 6 from 2,5-dichlorobenzylalcohol (Lancaster Synthesis). Mp. 226°-228° C.: TLC (SiO2 :CHCl3 /MeOH, 9:1) Rf=0.24.

Sources & evidence

ORD record
ord-9364716df0394e289c9c24426411d130
Source dataset
uspto-grants-1997_01
Patent number
US05597827

Reaction notes

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