Diisopropylamine → 2-tert-Butyl-5-[2-(2,4-difluoro-benzyl)-butyl]-3-methyl-4-oxo-tetrahydro-pyrimidine-1-carboxylic Acid Methyl Ester

HRID 2349430Notes

Reaction equation

HRID 2349430 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:13][O:14][C:15](=[O:16])[N:17]1[CH:18]([C:25]([CH3:26])([CH3:27])[CH3:28])[N:19]([CH3:24])[C:20](=[O:23])[CH2:21][CH2:22]1.[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[F:29][c:30]1[c:31]([CH2:37][CH:38]([CH2:39][CH3:40])[CH2:41][I:42])[cH:32][cH:33][c:34]([F:36])[cH:35]1>>[CH3:13][O:14][C:15](=[O:16])[N:17]1[CH:18]([C:25]([CH3:26])([CH3:27])[CH3:28])[N:19]([CH3:24])[C:20](=[O:23])[CH:21]([CH2:41][CH:38]([CH2:37][c:31]2[c:30]([F:29])[cH:35][c:34]([F:36])[cH:33][cH:32]2)[CH2:39][CH3:40])[CH2:22]1

Participants

6

Reactant 5

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 69268260HCID 69268260, compoundHCID 178418339ButyllithiumHCID 178501933HCID 178501933, compound

Product 1

HCID 692681512-tert-Butyl-5-[2-(2,4-difluoro-benzyl)-butyl]-3-methyl-4-oxo-tetrahydro-pyrimidine-1-carboxylic Acid Methyl Ester

Sources & evidence

ORD record
ord-6b2f9757a22b4744ac0e947ee4589a3b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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