huagongshe.com
HRID235062

反应详情

EQUATION

反应方程式

HRID 235062 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCOC(=O)CS
HCID12185

Ethyl mercaptoacetate

C4H8O2S

结构：N#Cc1cc([N+](=O)[O-])ccc1Cl
HCID85504

2-Chloro-5-nitrobenzonitrile

C7H3ClN2O2

PRODUCTS

生成物

1
结构：COC(=O)c1sc2ccc([N+](=O)[O-])cc2c1N
HCID2759774

methyl 3-amino-5-nitro-1-benzothiophene-2-carboxylate

C10H8N2O4S

收率 54%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

2-Chloro-5-nitrobenzonitrile (25.0 g, 136.9 mmol), commercially available, was treated with 1 equivalent ethyl thioglycolate and 1 equivalent K2CO3 in ethanol by the procedure described in Example 41A to yield the title compound (19.68 g, 54%). m.p. 208°-210° C. 1H NMR(300MHz, DMSO) δ9.23 (d, 1H), 8.29 (d, 1H), 8.11 (dd, 1H), 7.45 (br s, 2H), 4.29 (q, 2H), 1.31 (t, 3H). MS (DCI/NH3) m/e 284 (M+NH4)+.