Toluene → 4-(4-Fluoro-2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-piperidinecarbonitrile
Reaction equation
[CH3:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[Cl:1][CH2:2][CH2:3][N:4]([S:5](=[O:6])(=[O:7])[c:8]1[cH:9][cH:10][c:11]([CH3:14])[cH:12][cH:13]1)[CH2:15][CH2:16][Cl:17].[F:18][c:19]1[cH:20][c:21]([CH3:28])[c:22]([CH2:25][C:26]#[N:27])[cH:23][cH:24]1.[Li:29].[NH2-:30]>>[CH2:2]1[CH2:3][N:4]([S:5](=[O:6])(=[O:7])[c:8]2[cH:9][cH:10][c:11]([CH3:14])[cH:12][cH:13]2)[CH2:15][CH2:16][C:25]1([c:22]1[c:21]([CH3:28])[cH:20][c:19]([F:18])[cH:24][cH:23]1)[C:26]#[N:27]Participants
6
Sources & evidence
- ORD record
- ord-70b8d2411e5148a29c6cb4640e15378a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
Loading…