Toluene → [2-(2-Dimethylamino-ethyl)-benzo[b]thiophen-3-yl]-pyridin-2-yl-methanol

HRID 2350668Notes

Reaction equation

HRID 2350668 reaction equation
[Br:1][c:2]1[c:3]2[c:4]([s:5][c:6]1[CH2:7][CH2:8][N:9]([CH3:10])[CH3:11])[cH:12][cH:13][cH:14][cH:15]2.[CH3:16][N:17]([CH3:18])[CH2:19][CH2:20][N:21]([CH3:22])[CH3:23].[CH3:24][CH2:25][CH2:26][CH2:27][Li:28].[CH3:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[n:29]1[c:30]([CH:35]=[O:36])[cH:31][cH:32][cH:33][cH:34]1>>[c:2]1([CH:35]([c:30]2[n:29][cH:34][cH:33][cH:32][cH:31]2)[OH:36])[c:3]2[c:4]([s:5][c:6]1[CH2:7][CH2:8][N:9]([CH3:10])[CH3:11])[cH:12][cH:13][cH:14][cH:15]2

Participants

6

Reactant 5

HCID 1140TolueneHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 142732-PyridinecarboxaldehydeHCID 58591562[2-(3-Bromo-benzo[b]thiophen-2-yl)-ethyl]-dimethyl-amineHCID 178418339Butyllithium

Product 1

HCID 11522497[2-(2-Dimethylamino-ethyl)-benzo[b]thiophen-3-yl]-pyridin-2-yl-methanol

Sources & evidence

ORD record
ord-03bbe4de14ee468eae91fc934b3b80a6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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