2-Bromoethanol → 2-(Phenylsulfonyl)ethanol

1,000 ml of an aqueous solution containing 509 g (2.16 mol) of sodium benzenesulfonate (dihydrate) was heated to 80°-90° C. and stirred. To this solution were added at the same time 539 g (4.31 mol) of ethylenebromohydrin and 100 ml of an aqueous solution containing 45 g of sodium hydroxide while maintaining the pH of the reaction solution at 7-8. After the addition was completed, the reaction solution was further stirred for 2 hours at 80°-90° C. and then cooled to room temperature. Then, the reaction solution was extracted with ethyl acetate. The ethyl acetate was concentrated and distilled off under reduced pressure to yield 113 g of the desired product having a boiling point of 172 to 174° C./0.4 mmHg.

1. temperaturewas heated to 80°-90° C.
2. temperaturewhile maintaining the pH of the reaction solution at 7-8
3. additionAfter the addition
4. stirringthe reaction solution was further stirred for 2 hours at 80°-90° C.
5. extractionThen, the reaction solution was extracted with ethyl acetate
6. concentrationThe ethyl acetate was concentrated
7. distillationdistilled off under reduced pressure

ORD record

ord-26aded66af2b4aee8e3157ca3b82bbb1

Source dataset

uspto-grants-1989_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

USH0000691