反应详情

A solution of 10.0 g (42.0 mmoles) of the product of Example 1 in 50 ml of N-amino-homopiperidine was heated at reflux for 10 minutes. Upon cooling, a white, crystalline solid formed. The mixture was diluted with water (100 ml) and the solid was collected, washed with water, and air-dried to give 9.03 g of 10-(hexahydro-1H-azepin-1-yl)-2,10-dihydroimidazo[2,1-b]quinazolin-5(3H)-one. Melting point 206°-208° C. Total yield 76%.

1. temperatureat reflux for 10 minutes
2. temperatureUpon cooling
3. customa white, crystalline solid formed
4. customthe solid was collected
5. washwashed with water
6. customair-dried