HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Aminohomopiperidine → 10-(hexahydro-1H-azepin-1-yl)-2,10-dihydroimidazo[2,1-b]quinazolin-5(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Aminohomopiperidine | HCID 22198 | — |
| Reactant | 1-(2-Fluorobenzoyl)-2-methylthio-2-imidazoline | HCID 3236905 | — |
| Solvent | Water | HCID 962 | — |
| Product | 10-(hexahydro-1H-azepin-1-yl)-2,10-dihydroimidazo[2,1-b]quinazolin-5(3H)-one | HCID 14387119 | 76% |
Reaction Steps
A solution of 10.0 g (42.0 mmoles) of the product of Example 1 in 50 ml of N-amino-homopiperidine was heated at reflux for 10 minutes. Upon cooling, a white, crystalline solid formed. The mixture was diluted with water (100 ml) and the solid was collected, washed with water, and air-dried to give 9.03 g of 10-(hexahydro-1H-azepin-1-yl)-2,10-dihydroimidazo[2,1-b]quinazolin-5(3H)-one. Melting point 206°-208° C. Total yield 76%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04871732 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-bf592546447d4598b14378d415fb21a7 |
| Source note | uspto-grants-1989_10 |