反应详情

温度

160 °C

A mixture of 10.0 g (39.1 mmoles) of the product of Example 12 and 11.4 g (0.1114 mole) of 1-aminopiperidine was heated at 160° C. for 1 hour. The mixture was concentrated by Kugelrohr distillation and the residue was partitioned between methylene chloride and water. The organic layer was dried (sodium sulfate) and concentrated to a small volume. The resulting crystals were collected to give 5.74 g of 2,10-dihydro-10-(1-piperidinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one. Melting point 206°-207° C. Total yield 54%.

1. concentrationThe mixture was concentrated by Kugelrohr distillation
2. customthe residue was partitioned between methylene chloride and water
3. dry with materialThe organic layer was dried (sodium sulfate)
4. concentrationconcentrated to a small volume
5. customThe resulting crystals were collected