HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2350859Generated: October 26, 2026
1-Aminopiperidine → 2,10-dihydro-10-(1-piperidinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one
https://huagongshe.com/reaction/2350859
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Aminopiperidine | HCID 16658 | — |
| Reactant | 1-(2-Chloropyridine-3-carbonyl)-2-methylthio-2-imidazoline | HCID 14387135 | — |
| Product | 2,10-dihydro-10-(1-piperidinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one | HCID 14387137 | 54.1% |
Reaction Steps
A mixture of 10.0 g (39.1 mmoles) of the product of Example 12 and 11.4 g (0.1114 mole) of 1-aminopiperidine was heated at 160° C. for 1 hour. The mixture was concentrated by Kugelrohr distillation and the residue was partitioned between methylene chloride and water. The organic layer was dried (sodium sulfate) and concentrated to a small volume. The resulting crystals were collected to give 5.74 g of 2,10-dihydro-10-(1-piperidinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one. Melting point 206°-207° C. Total yield 54%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04871732 |
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| Source dataset | uspto-grants-1989_10 |
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| ORD ID | ord-eba6304544474dc7a7995d835908d775 |
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| Source note | uspto-grants-1989_10 |
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