反应详情

2.9 g of 2-dimethylaminobenzyl bromide hydrobromide are added to a solution of 1.56 g of 2-mercaptothieno[3,4-d]imidazole in 20 ml of anhydrous dimethylacetamide. A crystalline precipitate separates out in a weakly exothermic reaction. The mixture is stirred at room temperature for one hour, acetone is added, and the crystals are filtered off and dried in a stream of air. The crystalline solid is then introduced into saturated aqueous NaHCO3 solution, the mixture is heated briefly on a steam bath and, after stirring at room temperature, the crystals are filtered off. Treatment with active charcoal in ethanol and concentration is followed by solution being induced to crystallize with a little acetone.

1. customA crystalline precipitate separates out in a weakly exothermic reaction
2. filtrationthe crystals are filtered off
3. customdried in a stream of air
4. additionThe crystalline solid is then introduced into saturated aqueous NaHCO3 solution
5. temperaturethe mixture is heated briefly on a steam bath
6. stirringafter stirring at room temperature
7. filtrationthe crystals are filtered off
8. concentrationTreatment with active charcoal in ethanol and concentration
9. customto crystallize with a little acetone