Triethylamine → HCID 73655502, compound

Participants

Reaction Steps

In 5 ml of methylene chloride were dissolved 850 mg of ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate and 700 mg of 1-amino-2-fluorocyclopropane trifluoroacetate. After addition of 1 ml of triethylamine, the mixture was stirred at room temperature for 1 hour. The solvent was removed by distillation, and the residue was purified by column chromatography using 40 g of silica gel. From the chloroform eluate 450 mg of ethyl 3-(2-fluorocyclopropyl)amino-2-(2,3,4,5-tetrafluorobenzyl)acrylate was obtained.

Provenance & Evidence