Triethylamine → HCID 73655502, compound

HRID 2351030Notes

Reaction equation

HRID 2351030 reaction equation
C(O[CH:4]=[C:5]([C:11](=O)[C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([F:20])[C:13]=1[F:21])[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.FC(F)(F)C(O)=O.[NH2:30][CH:31]1[CH2:33][CH:32]1[F:34].C(N(CC)CC)C>C(Cl)Cl>[F:34][CH:32]1[CH2:33][CH:31]1[NH:30][CH:4]=[C:5]([CH2:11][C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([F:20])[C:13]=1[F:21])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 19848078HCID 19848078, compoundHCID 54346083Ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Product 1

HCID 73655502HCID 73655502, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 5 ml of methylene chloride were dissolved 850 mg of ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate and 700 mg of 1-amino-2-fluorocyclopropane trifluoroacetate. After addition of 1 ml of triethylamine, the mixture was stirred at room temperature for 1 hour. The solvent was removed by distillation, and the residue was purified by column chromatography using 40 g of silica gel. From the chloroform eluate 450 mg of ethyl 3-(2-fluorocyclopropyl)amino-2-(2,3,4,5-tetrafluorobenzyl)acrylate was obtained.

Workup

  1. customThe solvent was removed by distillation
  2. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-206ca3449e3f48adac550985287e0cd3
Source dataset
uspto-grants-1989_10
Patent number
US04871852

Reaction notes

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