Hydrazine hydrate (1:1) → HCID 11030084, compound

HRID 2351271Notes

Reaction equation

HRID 2351271 reaction equation
[N+](C1C=CC([O:8][C:9]([NH:11][C:12]2[S:13][CH:14]=[CH:15][N:16]=2)=O)=CC=1)([O-])=O.O.[NH2:20][NH2:21]>CO>[S:13]1[CH:14]=[CH:15][N:16]=[C:12]1[NH:11][C:9](=[O:8])[NH:20][NH2:21]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 156927894-Nitrophenyl 1,3-thiazol-2-ylcarbamate

Product 1

HCID 11030084HCID 11030084, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-(4-nitrophenoxycarbonyl)aminothiazole, 3.5 g (13 mMole) and 85% hydrazine hydrate, 4.0 ml (69 mMole) in 40 ml of methanol was stirred under nitrogen at 22° C. for 10 days. The mixture was cooled in ice. The insolubles were filtered, washed with cold methanol, dried and recrystallized from ethanol furnishing 780 mg of (thiazol-2-yl)semicarbazide, m.p. 166°-167° C., which was characterized by nuclear magnetic resonance, mass spectra, infrared spectra and elemental analyses.

Workup

  1. temperatureThe mixture was cooled in ice
  2. filtrationThe insolubles were filtered
  3. washwashed with cold methanol
  4. customdried
  5. customrecrystallized from ethanol furnishing 780 mg of (thiazol-2-yl)semicarbazide, m.p. 166°-167° C., which

Sources & evidence

ORD record
ord-4687f6961e52428c8acb8153a82544e4
Source dataset
uspto-grants-1989_10
Patent number
US04873224

Reaction notes

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