Sodium Hydroxide → HCID 14421557, compound

HRID 2351303Notes

Reaction equation

HRID 2351303 reaction equation
O[CH:2]([C:14]1[C:19]([CH3:20])=[C:18]([S:21][CH2:22][CH3:23])[CH:17]=[CH:16][N:15]=1)[CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=[C:5]1[SH:13].[OH-].[Na+]>>[CH2:22]([S:21][C:18]1[CH:17]=[CH:16][N:15]=[C:14]([CH:2]2[S:13][C:5]3=[N:6][C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=4[N:4]3[CH2:3]2)[C:19]=1[CH3:20])[CH3:23]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 178477294HCID 178477294, compound

Product 1

HCID 14421557HCID 14421557, compound

Conditions

Temperature
100 °C

Procedure

1-[2-Hydroxy-2-(4-ethylthio-3-methylpyrid-2-yl)ethyl]-2-mercaptobenzimidazole (0.01 mole) is dissolved in polyphosphoric acid (10 g) and the mixture heated at 100° C. for 2 hours with stirring. The mixture is then neutralised with sodium hydroxide solution and the product extracted with chloroform. Purification by column chromatography on silica gives the title compound.

Workup

  1. extractionthe product extracted with chloroform
  2. customPurification by column chromatography on silica

Sources & evidence

ORD record
ord-c7efd7455ddb4443b31c72b896ed574e
Source dataset
uspto-grants-1989_10
Patent number
US04873237

Reaction notes

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