Hydrochloric Acid → 6-Chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1,5-a)quinazoline-3-carboxylic acid

HRID 2351327Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:21])[N:5]([CH3:20])[C:6]1[N:7]2[CH:12]=[N:13][C:14]=1[C:15]([O:17]CC)=[O:16].O.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:21])[N:5]([CH3:20])[C:6]1[N:7]2[CH:12]=[N:13][C:14]=1[C:15]([OH:17])=[O:16]

Participants

Conditions

Temperature: 0 °C

Procedure

Ethyl 6-chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1,5-a)quinazoline-3-carboxylate (2.27g,7.4mmol) in a mixture of 50ml of ethanol, 25ml of water and 4.6ml of 4M aquous sodium hydroxide was refluxed for 1h. Then the mixture was cooled to 0° C. and neutralized by addition of 4.6ml of 4M hydrochloric acid. The precipitate was filtered off, rinsed with water and dried to give 2.lg (100%) of 6-chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1.5-a)quinazoline- 3-carboxylic acid.

Workup

temperaturewas refluxed for 1h
filtrationThe precipitate was filtered off
washrinsed with water
customdried

Sources & evidence

ORD record: ord-1e36a09d6d7d40308f5f4ed4b8dce3f1
Source dataset: uspto-grants-1989_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04873244

Reaction notes

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