Methanol → HCID 14623119, compound

Participants

Reaction Steps

To the mixture of 4-chloro-6-o-fluoro phenyl-2-(6-metyl-2-pyridinyl)pyrimidine (1 g) was added sodium methoxide prepared from methanol (10 ml) and metallic sodium (0.1 g). After the mixture was left to stand at room temperature for 1 hour, water (30 ml) and ethyl acetate (100 ml) were added thereto, and then extracted. After the extract was dried over anhydrous magnesium sulfate, it was concentrated under reduced pressure to obtain 4-o-fluorophenyl-6-methoxy-2-(6-methyl-2-pyridinyl)pyrimidine (0.82 g).

Provenance & Evidence