Methanol → HCID 14623119, compound

HRID 2351335Notes

Reaction equation

HRID 2351335 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[N:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[N:16]=2)[N:3]=1.[CH3:22][O-:23].[Na+].CO.[Na]>C(OCC)(=O)C.O>[F:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:6]1[CH:7]=[C:2]([O:23][CH3:22])[N:3]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[N:16]=2)[N:5]=1

Participants

7

Reactant 4

HCID 887MethanolHCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 14623118HCID 14623118, compound

Product 1

HCID 14623119HCID 14623119, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

To the mixture of 4-chloro-6-o-fluoro phenyl-2-(6-metyl-2-pyridinyl)pyrimidine (1 g) was added sodium methoxide prepared from methanol (10 ml) and metallic sodium (0.1 g). After the mixture was left to stand at room temperature for 1 hour, water (30 ml) and ethyl acetate (100 ml) were added thereto, and then extracted. After the extract was dried over anhydrous magnesium sulfate, it was concentrated under reduced pressure to obtain 4-o-fluorophenyl-6-methoxy-2-(6-methyl-2-pyridinyl)pyrimidine (0.82 g).

Workup

  1. waitAfter the mixture was left
  2. extractionextracted
  3. dry with materialAfter the extract was dried over anhydrous magnesium sulfate, it
  4. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-e302fca0861c4dc98d79193b3d42b186
Source dataset
uspto-grants-1989_10
Patent number
US04873248

Reaction notes

Loading…