Ammonia → 3-(1-Piperidinylmethyl)-1-pyrrolidineacetonitrile

HRID 2351380Notes

Reaction equation

HRID 2351380 reaction equation
C(N(C[CH:9]1[CH2:14][CH2:13][CH2:12][N:11]([CH2:15][C:16]#[N:17])[CH2:10]1)CCC)CC.[NH3:18]>ClCCl.CO>[N:18]1([CH2:9][CH:14]2[CH2:13][CH2:12][N:11]([CH2:15][C:16]#[N:17])[CH2:10]2)[CH2:10][CH2:9][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19846039HCID 19846039, compound

Product 1

HCID 198460353-(1-Piperidinylmethyl)-1-pyrrolidineacetonitrile

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

2-[3-[(dipropylamino)methyl]-piperidin-1-yl]acetonitrile in a yield of 76% of theory, RF 0.545 (Macherey-Nagel, PolygramRSIL G/UV254, pre-coated plastic sheets for TLC, eluant: dichloromethane/methanol/conc. ammonia 89/10/1 v/v);

Sources & evidence

ORD record
ord-837849fa20a84a009c057d22333e1fba
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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