Bromoacetonitrile → 4-[2-[(Diethylamino)methyl]-piperidin-1-yl]butane nitrile

HRID 2351381Notes

Reaction equation

HRID 2351381 reaction equation
[CH2:1]([N:4]([CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][NH:10]1)[CH2:5][CH2:6]C)[CH2:2]C.BrCC#N.C([N:22]([CH2:26][CH:27]1[CH2:32][CH2:31]CCN1CC#N)CCC)CC>ClCCl.C(OCC)(=O)C>[CH2:1]([N:4]([CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[CH2:31][CH2:32][CH2:27][C:26]#[N:22])[CH2:5][CH3:6])[CH3:2]

Participants

5

Reactant 3

HCID 11534BromoacetonitrileHCID 10490074(+/-)-2-[2-[(Dipropylamino)methyl]piperidin-1-yl]acetonitrileHCID 10798040N-(Piperidin-2-ylmethyl)-N-propylpropan-1-amine

Product 1

HCID 198459654-[2-[(Diethylamino)methyl]-piperidin-1-yl]butane nitrile

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

from 2-[(dipropylamino)methyl]piperidine and 2-bromoacetonitrile, (±)-2-[2-[(dipropylamino)methyl]piperidin-1-yl]acetonitrile, RF 0.9 (Macherey-Nagel, PolygramRSIL G/UV254, pre-coated plastic sheets for TLC, eluant: dichloromethane/ethyl acetate 50:50 v/v).

Sources & evidence

ORD record
ord-86fbff9b1c5a4f72bcb9803d828abca4
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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