Hydrochloric Acid → HCID 178484209, compound

HRID 2351392Notes

Reaction equation

HRID 2351392 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[OH:20][C@H:21]1[CH2:26][CH2:25][C@H:24]([CH2:27][NH:28][CH2:29][CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][N:31]2[CH2:36][CH2:37][NH:38][CH3:39])[CH2:23][CH2:22]1.Cl>CC(C)=O.C(O)(C)C>[OH:20][C@H:21]1[CH2:26][CH2:25][C@H:24]([CH2:27][NH:28][CH2:29][CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][N:31]2[CH2:36][CH2:37][N:38]([CH3:39])[C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)=[O:3])[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 178484208HCID 178484208, compound

Product 1

HCID 178484209HCID 178484209, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 22386392HCID 22386392, compoundSolvent

Procedure

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and trans-2-[2-[[(4-hydroxy-cyclohexyl)methylamino]methyl]-piperidin-1-yl]-N-methyl-ethanamine in a yield of 24% of theory. Colourless, substantially amorphous solid substance with an approximate m.p. 105°-120° C. M.p. of the hydrochloride 210°-213° C. (D.) (acetone/isopropanol).

Sources & evidence

ORD record
ord-2b6ce6a74ca7495496246c670a5fd69f
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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