11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → HCID 19846028, compound

HRID 2351394Notes

Reaction equation

HRID 2351394 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH3:20][N:21]([CH3:34])[CH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][N:25]1[CH2:30][CH2:31][NH:32][CH3:33]>>[CH3:34][N:21]([CH3:20])[CH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][N:25]1[CH2:30][CH2:31][N:32]([CH3:33])[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3]

Participants

3

Reactant 2

HCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 14210012HCID 14210012, compound

Product 1

HCID 19846028HCID 19846028, compoundYield 52%

Procedure

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[2-(dimethylamino)ethyl]-piperidin-1-yl]-N-methyl-ethanamine in a yield of 52% of theory. Colourless crystals, m.p. 114°-116° C. (after recrystallisation from diisopropylether and acetonitrile and decoction with water).

Workup

  1. customColourless crystals, m.p. 114°-116° C. (after recrystallisation from diisopropylether and acetonitrile and decoction with water)

Sources & evidence

ORD record
ord-7f2f68b9358a4d338bfdb1d4acb89d1f
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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