Ammonia → HCID 14210051, compound

HRID 2351402Notes

Reaction equation

HRID 2351402 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([C:12](Cl)=[O:13])[C:10]3[N:15]=[CH:16][CH:17]=[CH:18][C:9]=3[NH:8][C:7](=[O:19])[C:6]=2[CH:20]=1.[CH2:21]([N:23]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][N:28]1[CH2:33][CH2:34][NH2:35])[CH2:24][CH3:25])[CH3:22].N>ClCCl.C(OCC)(=O)C.C1CCCCC1.CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([C:12]([NH:35][CH2:34][CH2:33][N:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH:27]3[CH2:26][N:23]([CH2:21][CH3:22])[CH2:24][CH3:25])=[O:13])[C:10]3[N:15]=[CH:16][CH:17]=[CH:18][C:9]=3[NH:8][C:7](=[O:19])[C:6]=2[CH:20]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 142100002-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamineHCID 15107473HCID 15107473, compound

Product 1

HCID 14210051HCID 14210051, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 86583941HCID 86583941, compoundSolvent

Procedure

Prepared analogously to Example 2 from 8-bromo-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[(diethylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 25% of theory. Colourless crystals, m.p. 117°-119° C., RF 0.3 (Macherey-Nagel, PolygramRSIL G/UV254, pre-coated plastic sheets for TLC, eluant: dichloromethane/ethyl acetate/cyclohexane/methanol/conc. ammonia 58/25/8/8/1 v/v).

Sources & evidence

ORD record
ord-fc98e944ea434845bf21839b38bdab15
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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