Ammonia → HCID 14210051, compound

Participants

Reaction Steps

Prepared analogously to Example 2 from 8-bromo-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[(diethylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 25% of theory. Colourless crystals, m.p. 117°-119° C., RF 0.3 (Macherey-Nagel, PolygramRSIL G/UV254, pre-coated plastic sheets for TLC, eluant: dichloromethane/ethyl acetate/cyclohexane/methanol/conc. ammonia 58/25/8/8/1 v/v).

Provenance & Evidence