2-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamine → 4-[[[2-[2-[(Diethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-one

HRID 2351407Notes

Reaction equation

HRID 2351407 reaction equation
Cl[C:2]([N:4]1[C:10]2[C:11]([CH3:15])=[N:12][N:13]([CH3:14])[C:9]=2[C:8](=[O:16])[NH:7][C:6]2[N:17]=[CH:18][CH:19]=[CH:20][C:5]1=2)=[O:3].[CH2:21]([N:23]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][N:28]1[CH2:33][CH2:34][NH2:35])[CH2:24][CH3:25])[CH3:22]>C(#N)C>[CH2:21]([N:23]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][N:28]1[CH2:33][CH2:34][NH:35][C:2]([N:4]1[C:10]2[C:11]([CH3:15])=[N:12][N:13]([CH3:14])[C:9]=2[C:8](=[O:16])[NH:7][C:6]2[N:17]=[CH:18][CH:19]=[CH:20][C:5]1=2)=[O:3])[CH2:24][CH3:25])[CH3:22]

Participants

4

Reactant 2

HCID 142100002-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamineHCID 198460214-(Chlorocarbonyl)-1,3-dimethyl-1,4,9,10-tetrahydro-pyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-one

Product 1

HCID 142100854-[[[2-[2-[(Diethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-oneYield 17%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to Example 2 from 4-(chlorocarbonyl)-1,3-dimethyl-1,4,9,10-tetrahydro-pyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-one and 2-[2-[(diethylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 17% of theory. Colourless crystals, m.p. 138°-139° C. (acetonitrile).

Sources & evidence

ORD record
ord-11cb8e5c42f3418ea1999bc939a0951b
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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