HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamine → 4-[[[2-[2-[(Diethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamine | HCID 14210000 | — |
| Reactant | 4-(Chlorocarbonyl)-1,3-dimethyl-1,4,9,10-tetrahydro-pyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-one | HCID 19846021 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[[[2-[2-[(Diethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-one | HCID 14210085 | 17% |
Reaction Steps
Prepared analogously to Example 2 from 4-(chlorocarbonyl)-1,3-dimethyl-1,4,9,10-tetrahydro-pyrazolo[4,3-e]pyrido[2,3-b][1,4]diazepin-10-one and 2-[2-[(diethylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 17% of theory. Colourless crystals, m.p. 138°-139° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-11cb8e5c42f3418ea1999bc939a0951b |
| Source note | uspto-grants-1989_10 |