HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → (+)-9-Chloro-11-[[[2-[2-[(diethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 9-Chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14209976 | — |
| Reactant | 2-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamine | HCID 14210000 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (+)-9-Chloro-11-[[[2-[2-[(diethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14210044 | 50% |
Reaction Steps
Prepared analogously to Example 2 from 9-chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and (+)-2-[2-[(diethylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 50% of theory. Colourless crystals, m.p. 169°-170° C. (from acetonitrile, using activated charcoal); [α]D20 =+11.88° (dilute hydrochloric acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-b459965570564ae5a9db003fb8c7670d |
| Source note | uspto-grants-1989_10 |