HRID2351426

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

反应SMILES：Cc1ccc2c(c1)N(C(=O)Cl)c1ncccc1NC2=O

HCID15107471

未命名化合物

HCID19846011

未命名化合物

PRODUCTS

产物

反应SMILES：CCCN(CCC)CCCC1CCN(CCNC(=O)N2c3cc(C)ccc3C(=O)Nc3cccnc32)CC1

HCID19845948

未命名化合物

收率 63%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID69163855

未命名化合物

PROCEDURE

实验过程

Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[4-[3-(dipropylamino)propyl]-piperidin-1-yl]ethanamine in a yield of 63% of theory. Colourless crystals, m.p. 195° C. (D.), RF =0.5 (Macherey-Nagel, Polygram® SIL G UV254, pre-coated plastic sheets for TLC, eluant: dichloromethane/cyclohexane/methanol/conc. ammonia 68/15/15/15/2 v/v).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-c4c45fdccaa844499c1de97ccbca122e
来源数据集: uspto-grants-1989_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04873236
来源说明: uspto-grants-1989_10

反应SMILES

Cl[C:2]([N:4]1[C:10]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=2[C:8](=[O:16])[NH:7][C:6]2[CH:17]=[CH:18][CH:19]=[N:20][C:5]1=2)=[O:3].[CH2:21]([N:24]([CH2:37][CH2:38][CH3:39])[CH2:25][CH2:26][CH2:27][CH:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][NH2:36])[CH2:30][CH2:29]1)[CH2:22][CH3:23].N>ClCCl.C1CCCCC1.CO>[CH2:37]([N:24]([CH2:21][CH2:22][CH3:23])[CH2:25][CH2:26][CH2:27][CH:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][NH:36][C:2]([N:4]2[C:10]3[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=3[C:8](=[O:16])[NH:7][C:6]3[CH:17]=[CH:18][CH:19]=[N:20][C:5]2=3)=[O:3])[CH2:30][CH2:29]1)[CH2:38][CH3:39]