HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5,11-Dihydro-11-[[[2-[4-[3-(dipropylamino)propyl]-piperidin-1-yl]ethyl]amino]carbonyl]-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 11-(chlorocarbonyl)-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 15107471 | — |
| Reactant | 2-[4-[3-(Dipropylamino)propyl]-piperidin-1-yl]ethanamine | HCID 19846011 | — |
| Solvent | Dichloromethane cyclohexane methanol | HCID 69163855 | — |
| Product | 5,11-Dihydro-11-[[[2-[4-[3-(dipropylamino)propyl]-piperidin-1-yl]ethyl]amino]carbonyl]-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19845948 | 63% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[4-[3-(dipropylamino)propyl]-piperidin-1-yl]ethanamine in a yield of 63% of theory. Colourless crystals, m.p. 195° C. (D.), RF =0.5 (Macherey-Nagel, Polygram® SIL G UV254, pre-coated plastic sheets for TLC, eluant: dichloromethane/cyclohexane/methanol/conc. ammonia 68/15/15/15/2 v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-c4c45fdccaa844499c1de97ccbca122e |
| Source note | uspto-grants-1989_10 |