HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+)-4-[[[2-[2-[(Diethylamino)methyl]-piperidin-l-yl]ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14209980 | — |
| Reactant | 2-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamine | HCID 14210000 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (+)-4-[[[2-[2-[(Diethylamino)methyl]-piperidin-l-yl]ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14210081 | 55% |
Reaction Steps
Prepared analogously to Example 1 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and (+)-2-[2-[(diethylamino)methyl]-piperidin-l-yl]ethanamine in a yield of 55% of theory. Colourless crystals, m.p. 131°-132° C. (acetonitrile); [α]D20 =-13.66° (dilute aqueous hydrochloric acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-1c230f06371e40ba9bbfc61c8b9a5034 |
| Source note | uspto-grants-1989_10 |