11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → HCID 19845924, compound

HRID 2351447Notes

Reaction equation

HRID 2351447 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH3:20][CH:21]([N:23]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[CH2:34][CH2:35][NH2:36])[CH:24]([CH3:26])[CH3:25])[CH3:22]>C(#N)C>[CH3:26][CH:24]([N:23]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[CH2:34][CH2:35][NH:36][C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3])[CH:21]([CH3:20])[CH3:22])[CH3:25]

Participants

4

Reactant 2

HCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 19846010HCID 19846010, compound

Product 1

HCID 19845924HCID 19845924, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[[bis(methylethyl)amino]methyl]-piperidin-l-yl]ethanamine in a yield of 34% of theory. Colourless crystals, m.p. 181°-182° C. (acetonitrile using activated charcoal).

Sources & evidence

ORD record
ord-73b6046a90f54c2292a8a878940c2d53
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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