HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → AF-DX-384
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine | HCID 10868438 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | AF-DX-384 | HCID 119357 | 90% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and (-)-2-[2-[(dipropylamino)methyl]-piperidin-l-yl]ethanamine in a yield of 90% of theory. Colourless crystals, m.p. 164°-165° C. (acetonitrile); [α]D20 =-7.62° (dilute aqueous hydrochloric acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-9bcbb34f405e4f28a7507088e2acf3f1 |
| Source note | uspto-grants-1989_10 |