HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinebutanamine, N,N-diethyl- → 9-Chloro-11-[[[2-[4-[4-(diethylamino)butyl]-piperidin-l-yl]ethyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinebutanamine, N,N-diethyl- | HCID 10081918 | — |
| Reactant | 11-[[[2-bromo-ethyl]amino]carbonyl]-9-chloro-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19845989 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 9-Chloro-11-[[[2-[4-[4-(diethylamino)butyl]-piperidin-l-yl]ethyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 53644710 | 19% |
Reaction Steps
Prepared analogously to Example 109 from 11-[[[2-bromo-ethyl]amino]carbonyl]-9-chloro-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-[4-(diethylamino)butyl]piperidine, but using dimethylformamide instead of acetonitrile, in a yield of 19% of theory. Colourless crystals, m.p. 157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-e1d70b939cfe4d2dbe3915076f2d8b47 |
| Source note | uspto-grants-1989_10 |