反应详情

Prepared analogously to Example 109 from 4-[[[2-bromo-ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 4-[3-(hexahydro-1H-azepin-l-yl)propyl]piperidine in a yield of 29% of theory. Colourless crystals m.p. 144°-145° C. RF =0.5 (Macherey-Nagel, PolygramRSIL G/UV254, pre-coated plastic sheets for TLC; eluant: dichloromethane/cyclohexane/methanol/conc. ammonia 68/15/15/2 v/v).