HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4,9-Dihydro-4-[[[2-[4-[3-(hexahydro-1H-azepin-1-yl)propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-[[[2-bromo-ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 19846026 | — |
| Reactant | 4-[3-(hexahydro-1H-azepin-l-yl)propyl]piperidine | HCID 19846068 | — |
| Solvent | Dichloromethane cyclohexane methanol | HCID 69163855 | — |
| Product | 4,9-Dihydro-4-[[[2-[4-[3-(hexahydro-1H-azepin-1-yl)propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 53807851 | 29% |
Reaction Steps
Prepared analogously to Example 109 from 4-[[[2-bromo-ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 4-[3-(hexahydro-1H-azepin-l-yl)propyl]piperidine in a yield of 29% of theory. Colourless crystals m.p. 144°-145° C. RF =0.5 (Macherey-Nagel, PolygramRSIL G/UV254, pre-coated plastic sheets for TLC; eluant: dichloromethane/cyclohexane/methanol/conc. ammonia 68/15/15/2 v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-8171cb111d824dd79ecffa8bcc522215 |
| Source note | uspto-grants-1989_10 |