Hydrochloric Acid → HCID 15613926, compound

HRID 2351503Notes

Reaction equation

HRID 2351503 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[Cl:15])[O:11][C:10]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH:26](Cl)[C:27]([O:29]CC)=O)=[CH:21][CH:20]=1)([CH3:16])[CH2:9][C:8]2=[O:33])(=O)C.[NH2:34][C:35](N)=[S:36].S1(CCCC1)(=O)=[O:39].Cl>COCCO>[Cl:15][C:14]1[CH:13]=[C:12]2[C:7]([C:8](=[O:33])[CH2:9][C:10]([CH2:17][O:18][C:19]3[CH:20]=[CH:21][C:22]([CH2:25][CH:26]4[S:36][C:35](=[O:39])[NH:34][C:27]4=[O:29])=[CH:23][CH:24]=3)([CH3:16])[O:11]2)=[CH:6][C:5]=1[OH:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 15671162HCID 15671162, compound

Product 1

HCID 15613926HCID 15613926, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Following a procedure similar to that described in Example 1, but using 780 mg of ethyl 3-[4-(6-acetoxy-7-chloro-2-methyl-4-oxochroman-2-ylmethoxy)phenyl]-2-chloropropionate (prepared as described in Preparation 37), 360 mg of thiourea, 3 ml of sulfolane, 10 ml of ethylene glycol monomethyl ether and 5 ml of 3N aqueous hydrochloric acid, 286 mg of the title compound were obtained as a greyish white powder, softening at 195°-206° C.

Sources & evidence

ORD record
ord-8208b1480c7a4bd2a6bc111e0503a715
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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