Hydrochloric Acid → HCID 15613924, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 1, but using 1 g of ethyl 3-[4-(7-acetoxy-2,8-dimethylchroman-2-ylmethoxy)phenyl]-2-chloropropionate (prepared as described in Preparation 41), 0.22 g of thiourea, 1.5 ml of sulfolane, 10 ml of ethylene glycol monomethyl ether and 4 ml of 3N aqueous hydrochloric acid, 586 mg of the title compound were obtained as a pale yellow powder, softening at 68°-71° C.

Provenance & Evidence