Hydrochloric Acid → HCID 15613924, compound

HRID 2351504Notes

Reaction equation

HRID 2351504 reaction equation
C([O:4][C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([CH2:9][CH2:10][C:11]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH:26](Cl)[C:27](OCC)=[O:28])=[CH:21][CH:20]=3)([CH3:16])[O:12]2)=[CH:7][CH:6]=1)(=O)C.[NH2:33][C:34](N)=[S:35].S1(CCCC1)(=O)=[O:38].Cl>COCCO>[OH:4][C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([CH2:9][CH2:10][C:11]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH:26]4[S:35][C:34](=[O:38])[NH:33][C:27]4=[O:28])=[CH:21][CH:20]=3)([CH3:16])[O:12]2)=[CH:7][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 15671143HCID 15671143, compound

Product 1

HCID 15613924HCID 15613924, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Following a procedure similar to that described in Example 1, but using 1 g of ethyl 3-[4-(7-acetoxy-2,8-dimethylchroman-2-ylmethoxy)phenyl]-2-chloropropionate (prepared as described in Preparation 41), 0.22 g of thiourea, 1.5 ml of sulfolane, 10 ml of ethylene glycol monomethyl ether and 4 ml of 3N aqueous hydrochloric acid, 586 mg of the title compound were obtained as a pale yellow powder, softening at 68°-71° C.

Sources & evidence

ORD record
ord-78140991ab4147a8ba1e9c097dcb073f
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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