Hydrochloric Acid → HCID 19846295, compound

HRID 2351505Notes

Reaction equation

HRID 2351505 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:38]=[CH:37][C:12]([O:13][CH2:14][C:15]([O:24][C:25]3[C:34]([CH3:35])=[C:33]4[C:28]([C:29](=[O:36])[CH2:30][CH2:31][O:32]4)=[CH:27][CH:26]=3)([CH3:23])[C:16]([O:18]C(C)(C)C)=[O:17])=[CH:11][CH:10]=2)[S:3]1.Cl>O1CCOCC1>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:38]=[CH:37][C:12]([O:13][CH2:14][C:15]([O:24][C:25]3[C:34]([CH3:35])=[C:33]4[C:28]([C:29](=[O:36])[CH2:30][CH2:31][O:32]4)=[CH:27][CH:26]=3)([CH3:23])[C:16]([OH:18])=[O:17])=[CH:11][CH:10]=2)[S:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19846291HCID 19846291, compound

Product 1

HCID 19846295HCID 19846295, compoundYield 93.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 100 mg of t-butyl 2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-2,8-dimethyl-4-oxochroman-7-yloxyacetate (prepared as described in Example 12) and 2 ml of a 4N solution of hydrogen chloride in dioxane was allowed to stand overnight at room temperature. At the end of this time, the solvent was removed from the reaction mixture by evaporation under reduced pressure. The resulting residue was washed with water, to afford 84 mg of the title compound as a pale orange powder, softening at 176°-179° C.

Workup

  1. customAt the end of this time, the solvent was removed from the reaction mixture by evaporation under reduced pressure
  2. washThe resulting residue was washed with water

Sources & evidence

ORD record
ord-b52ee45a960e4a19b5bc653954e7f95f
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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