反应详情

To 3-methyl-2-pyridinecarboxamide (15.0 o, 0.11 mole) are added BF3.OEt2 (14.0 mL, 0.11 mole) and tetrahydrofuran (75 mL). After about 5 minutes, aniline (10.3 g, 0.11 mole) is slowly added and the solution is heated at reflux for 5 hours. The reaction is cooled and diluted with water and the oroduct is extracted into ethyl acetate. The solvent is removed and the residue is purified by silica gel chromatography to give 8.32 g (0.39 mole, 35%) of N-phenyl-3-methyl-2-pyridinecarboxamide.

1. temperaturethe solution is heated
2. temperatureat reflux for 5 hours
3. temperatureThe reaction is cooled
4. extractionthe oroduct is extracted into ethyl acetate
5. customThe solvent is removed
6. customthe residue is purified by silica gel chromatography