HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | HCID 14737099 | HCID 14737099 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1-one | HCID 3017788 | — |
Reaction Steps
The following operations are performed under dry nitrogen. A solution of 40.0 gr 3-carboxy-3-(4-fluorophenyl)-indan-1-one in 50 ml N-methylpyrrolidone is heated to 100° C. and stirred for 2 hours at this temperature. The reaction-mixture is cooled and poured into 250 ml water. Subsequent extractive work-up with ethylacetate give the product 3-(4-fluorophenyl)-indan-1-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873344 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-c155566c42254584b25ac25f70292ef7 |
| Source note | uspto-grants-1989_10 |